Items where Author is "Szabo, C."

Mabley, J.G., Pacher, Pal, Murthy, K.G.K., Williams, W., Southan, G.J., Salzman, A.L. and Szabo, C. (2008) The novel inosine analogue INO-2002 protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type 1 diabetes Journal of Endocrinology, 198 (3). pp. 581-589. ISSN 0022-0795

Mabley, J.G., Horvath, E.M., Murthy, K.G.K., Zsengeller, Z., Vaslin, A., Benko, R., Kollai, M. and Szabo, C. (2005) Gender differences in the endotoxin-induced inflammatory and vascular responses: potential role of poly(ADP-ribose) polymerase activation Journal of pharmacology and experimental therapeutics, 315 . pp. 812-820. ISSN 1521-0103

Obrosova, I.G., Mabley, J.G., Zsengeller, Z., Charniauskaya, T., Abatan, O.I., Groves, J.T. and Szabo, C. (2005) Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst Faseb journal, 19 (3). pp. 401-403. ISSN 1530-6860

Mabley, J.G., Pacher, P., Deb, A., Wallace, R., Elder, R.H. and Szabo, C. (2005) Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation Faseb journal, 19 (2). pp. 290-292. ISSN 1530-6860

Pacher, P., Obrosova, I.G., Mabley, J.G. and Szabo, C. (2005) Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies Current medicinal chemistry, 12 (3). pp. 267-275. ISSN 0929-8673

Mabley, J.G., Pacher, P., Deb, A., Wallace, R., Elder, R.H. and Szabo, C. (2004) Potential role for 8-oxoguanine DNA glycosylase in regulating inflammation Faseb Journal . ISSN 0892-6638

Pacher, P., Vaslin, A., Benko, R., Mabley, J.G., Liaudet, L., Hasko, G., Marton, A., Batkai, S., Kollai, M. and Szabo, C. (2004) A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging Journal of pharmacology and experimental therapeutics, 311 . pp. 485-491. ISSN 1521-0103

Scott, G.S., Kean, R.B., Mikheeva, T., Fabis, M.J., Mabley, J.G., Szabo, C. and Hooper, D.C. (2004) The Therapeutic Effects of PJ34 [N-(6-Oxo-5,6-dihydrophenanthridin-2-yl) -N,N-dimethylacetamide.HCl], a Selective Inhibitor of Poly(ADP-Ribose) Polymerase, in Experimental Allergic Encephalomyelitis Are Associated with Immunomodulation Journal of pharmacology and experimental therapeutics, 310 . pp. 1053-1061. ISSN 1521-0103

Pacher, P., Mabley, J.G., Liaudet, L., Evgenov, O.V., Marton, A., Hasko, G., Kollai, M. and Szabo, C. (2004) Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure American journal of physiology - Heart and circulatory physiology, 287 . pp. 2132-2137. ISSN 1522-1539

Mabley, J.G., Southan, G.J., Salzmann, A.L. and Szabo, C. (2004) The combined inducible nitric oxide synthase inhibitor and free radical scavenger guanidinoethyldisulfide prevents multiple low-dose streptozotocin-induced diabetes in vivo and interleukin-1[beta]-induced suppression of islet insulin secretion in vitro Pancreas, 28 (2). pp. 39-44. ISSN 0885-3177

Komjati, K., Mabley, J.G., Virag, L., Southan, G.J., Salzman, A.L. and Szabo, C. (2004) Poly(ADP-ribose) polymerase inhibition protects neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke. International journal of molecular medicine, 13 (3). pp. 373-382. ISSN 1021-335X

Murakami, K., Enkhbaatar, P., Shimoda, K., Cox, R.A., Burke, A.S., Hawkins, H.K., Traber, L.D., Schmalstieg, F.C., Salzman, A.L., Mabley, J.G., Komjati, K., Pacher, P., Zsengeller, Z., Szabo, C. and Traber, D.L. (2004) Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis Shock, 21 (2). pp. 126-133. ISSN 1073-2322

Jagtap, P., Southan, G.J., Baloglu, E., Ram, E., Mabley, J.G., Marton, A., Salzman, A.L. and Szabo, C. (2004) The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) Bioorganic & medicinal chemistry letters, 14 . pp. 81-85. ISSN 0960-894X

Szabo, C., Pacher, P., Zsengeller, Z., Vaslin, A., Komjati, K., Benko, R., Chen, M., Mabley, J.G. and Kollai, M. (2004) Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation Molecular medicine, 10 (1-6). pp. 28-35. ISSN 1107-3756

Bai, P., Mabley, J.G., Liaudet, L., Virag, L., Szabo, C. and Pacher, P. (2004) Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity Oncology reports, 11 . pp. 505-508. ISSN 1021-335X

Pacher, P., Mabley, J.G., Liaudet, L., Evgenov, O.V., Southan, G.J., Abdelkarim, G.E., Szabo, C. and Salzman, A.L. (2003) Topical administration of a novel nitric oxide donor, linear polyethylenimine-nitric oxide/nucleophile adduct (DS1), selectively increases vaginal blood flow in anesthetized rats International journal of impotence, 15 (6). pp. 461-464. ISSN 1476-5489

Evgenov, O.V., Pacher, P., Williams, W., Evgenov, N.V., Mabley, J.G., Cicila, J., Siko, J.B., Salzman, A.L. and Szabo, C. (2003) Parenteral administration of glipizide sodium salt, an inhibitor of adenosine triphosphate-sensitive potassium channels, prolongs short-term survival after severe controlled hemorrhage in rats Critical care medicine, 31 (10). pp. 2429-2436. ISSN 1530-0293

Shimoda, K., Murakami, K., Enkhbaatar, P., Traber, L.D., Cox, R.A., Hawkins, H.K., Schmalstieg, F.C., Komjati, K., Mabley, J.G., Szabo, C., Salzman, A.L. and Traber, D.L. (2003) Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep American journal of physiology-lung cellular and molecular physiology, 285 (1). pp. 240-249. ISSN 1040-0605

Suarez-Pinzon, W.L., Mabley, J.G., Power, R., Szabo, C. and Rabinovitch, A. (2003) Poly (ADP-Ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes Diabetes, 52 (7). pp. 1683-1688. ISSN 0012-1797

Mabley, J.G., Soriano, F.G., Pacher, P., Hasko, G., Marton, A., Wallace, R., Salzman, A.L. and Szabo, C. (2003) The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide, is protective in two murine models of colitis European journal of pharmacology, 466 (3). pp. 323-329. ISSN 0014-2999

Mabley, J.G., Rabinovitch, A., Suarez-Pinzon, W.L., Hasko, G., Pacher, P., Power, R., Southan, G.J., Salzman, A.L. and Szabo, C. (2003) Inosine protects against the development of diabetes in multiple-low-dose streptozotocin and nonobese diabetic house Models of Type 1 Diabetes Molecular medicine, 9 (3-4). pp. 96-104. ISSN 1076-1551

Liaudet, L., Szabo, C., Evgenov, O.V., Murthy, K.G.K., Pacher, P., Virag, L., Mabley, J.G., Marton, A., Soriano, F.G., Kirov, M.Y., Bjertnaes, L.J. and Salzman, A.L. (2003) Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis. Shock, 19 (2). pp. 131-137. ISSN 1073-2322

Pacher, P., Liaudet, L., Bai, P., Mabley, J.G., Kaminski, P.M., Virag, L., Deb, A., Szabo, E., Ungvari, Z., Wolin, M.S., Groves, J.T. and Szabo, C. (2003) Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction Circulation, 107 (6). pp. 896-904. ISSN 1524-4539

Mabley, J.G., Pacher, P., Liaudet, L., Soriano, F.G., Hasko, G., Marton, A., Szabo, C. and Salzman, A.L. (2003) Inosine reduces inflammation and improves survival in a murine model of colitis American journal of physiology-gastrointestinal and liver physiology, 284 (1). pp. 138-144. ISSN 0193-1857

Lohinai, Z., Mabley, J.G., Feher, E., Marton, A., Komjati, K. and Szabo, C. (2003) Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis Journal of dental research, 82 (12). pp. 987-992. ISSN 1544-0591

Pacher, P., Cziraki, A., Mabley, J.G., Liaudet, L., Papp, L and Szabo, C. (2002) Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents Biochemical pharmacology, 64 (12). pp. 1785-1791. ISSN 0006-2952

Szabo, C., Mabley, J.G., Moeller, S.M., Shimanovich, R., Pacher, P., Virag, L., Soriano, F.G., Van Duzer, J.H., Williams, W., Salzmann, A.L. and Groves, J.T. (2002) Part I: Pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst Molecular medicine, 8 (10). pp. 571-580. ISSN 1076-1551

Mabley, J.G., Liaudet, L., Pacher, P., Southan, G.J., Salzman, A.L. and Szabo, C. (2002) Part II: beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis Molecular medicine, 8 (10). pp. 581-590. ISSN 1076-1551

Liaudet, L., Deb, A., Pacher, P., Mabley, J.G., Murthy, K.G.K., Salzman, A.L. and Szabo, C. (2002) The flagellin-TLR5 axis: therapeutic opportunities Drug news and perspectives, 15 (7). pp. 397-409. ISSN 0214-0934

Pacher, P., Liaudet, L., Mabley, J.G., Komjati, K. and Szabo, C. (2002) Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure Journal of the American College of Cardiology, 40 (5). pp. 1006-1016. ISSN 0735-1097

Nemeth, Z.H., Deitch, E.A., Szabo, C., Mabley, J.G., Pacher, P., Fekete, Z., Hauser, C.J. and Hasko, G. (2002) Na+/H+ exchanger blockade inhibits enterocyte inflammatory response and protects against colitis American journal of physiology-gastrointestinal and liver physiology, 283 (1). pp. 122-132. ISSN 0193-1857

Pacher, P., Mabley, J.G., Soriano, F.G., Liaudet, L. and Szabo, C. (2002) Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging International journal of molecular medicine, 9 (6). pp. 659-664. ISSN 1107-3756

Jagtap, P., Soriano, F.G., Virag, L., Liaudet, L., Mabley, J.G., Szabo, E., Hasko, G., Marton, A., Lorigados, C.B., Gallyas, F., Sumegi, B., Hoyt, D.G., Baloglu, E., VanDuzer, J.H., Salzman, A.L., Southan, G.J. and Szabo, C. (2002) Novel phenanthridinone inhibitors of poly(adenosine 5'-diphosphate-ribose) synthetase: Potent cytoprotective and antishock agents*. Critical care medicine, 30 (5). pp. 1071-1082. ISSN 0090-3493

Hasko, G., Mabley, J.G., Nemeth, Z.H., Pacher, P., Deitch, E.A. and Szabo, C. (2002) Poly(ADP-ribose) polymerase is a regulator of chemokine production: relevance for the pathogenesis of shock and inflammation Molecular medicine, 8 (5). pp. 283-289. ISSN 1076-1551

Liaudet, L., Mabley, J.G., Pacher, P., Virag, L., Soriano, F.G., Marton, A., Hasko, G., Deitch, E.A. and Szabo, C. (2002) Inosine exerts a broad range of antiinflammatory effects in a hurine model of acute lung injury Annals of Surgery, 235 (4). pp. 568-578. ISSN 1528-1140

Soriano, F.G., Liaudet, L., Szabo, E., Virag, L., Mabley, J.G., Pacher, P. and Szabo, C. (2002) Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice Shock, 17 (4). pp. 286-292. ISSN 1073-2322

Pacher, P., Liaudet, L., Bai, P., Virag, L., Mabley, J.G., Hasko, G. and Szabo, C. (2002) Activation of poly(ADP-Ribose) polymerase contributes to development of doxorubicin-induced heart failure Journal of pharmacology and experimental therapeutics, 300 (3). pp. 862-867. ISSN 1521-0103

Pacher, P., Mabley, J.G., Soriano, F.G., Liaudet, L., Komjati, K. and Szabo, C. (2002) Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation British journal of pharmacology, 135 (6). pp. 1347-1350. ISSN 0007-1188

Mabley, J.G., Pacher, P., Southan, G.J., Salzman, A.L. and Szabo, C. (2002) Nicotine reduces the incidence of type I diabetes in mice Journal of pharmacology and experimental therapeutics, 300 (3). pp. 876-881. ISSN 1521-0103

Liaudet, L., Pacher, P., Mabley, J.G., Virag, L., Soriano, F.G., Hasko, G. and Szabo, C. (2002) Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation American journal of respiratory and critical care medicine, 165 (3). pp. 372-377. ISSN 1073-449X

Liaudet, L., Murthy, K.G.K., Mabley, J.G., Pacher, P., Soriano, F.G., Salzman, A.L. and Szabo, C. (2002) Comparison of inflammation, organ damage, and oxidant stress induced by salmonella enterica serovar huenchen flagellin and serovar enteritidis lipopolysaccharide Infection and immunity, 70 (1). pp. 192-198. ISSN 0019-9567

Mabley, J.G., Hasko, G., Liaudet, L., Soriano, F.G., Southan, G.J., Salzman, A.L. and Szabo, C. (2002) NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes Journal of endocrinology, 173 (3). pp. 457-464. ISSN 0022-0795

Pacher, P., Liaudet, L., Soriano, F.G., Mabley, J.G., Szabo, E. and Szabo, C. (2002) The role of poly(ADP-Ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes Diabetes, 51 . pp. 514-521. ISSN 1939-327X

Mabley, J.G., Jagtap, P., Perretti, M., Getting, S.J., Salzman, A.L., Virag, L., Szabo, E., Soriano, F.G., Liaudet, L., Abdelkarim, G.E., Hasko, G., Marton, A., Southan, G.J. and Szabo, C. (2001) Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase Inflammation research, 50 (11). pp. 561-569. ISSN 1023-3830

Liaudet, L., Mabley, J.G., Soriano, F.G., Pacher, P., Marton, A., Hasko, G. and Szabo, C. (2001) Inosine reduces systemic inflammation and improves survival in septic shock induced by cecal ligation and puncture American journal of respiratory and critical care medicine, 164 (7). pp. 1213-1220.

Nemeth, Z.H., Mabley, J.G., Deitch, E.A., Szabo, C. and Hasko, G. (2001) Inhibition of the Na+/H+ antiporter suppresses IL-12 p40 production by mouse macrophages Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1539 (3). pp. 233-242. ISSN 0167-4889

Suarez-Pinzon, W.L., Mabley, J.G., Strynadka, K., Power, R.F., Szabo, C. and Rabinovitch, A. (2001) An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice Journal of autoimmunity, 16 (4). pp. 449-455. ISSN 0896-8411

Soriano, F.G., Virag, L., Jagtap, P., Szabo, E., Mabley, J.G., Liaudet, L., Marton, A., Hoyt, D.G., Murthy, K.G.K., Salzman, A.L., Southan, G.J. and Szabo, C. (2001) Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation Nature medicine, 7 (1). pp. 108-113. ISSN 1546-170X

Lakey, J.R.T., Suariz-Pinzon, W.L., Strynadka, K., Korbutt, G.S., Rajotte, R., Mabley, J.G., Szabo, C. and Rabinovitch, A. (2001) Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells Laboratory investigation, 81 (12). pp. 1683-1692. ISSN 0023-6837

Soriano, F.G., Pacher, P., Mabley, J.G., Liaudet, L. and Szabo, C. (2001) Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-Ribose) polymerase Circulation research, 89 (8). pp. 684-691. ISSN 1524-4571