Kockisch, S., Rees, G.D., Tsibouklis, J. and Smart, J.D. (2005) Mucoadhesive, triclosan-loaded polymer microspheres for application to the oral cavity: preparation and controlled release characteristics European Journal of Pharmaceutics and Biopharmaceutics, 59 (1). pp. 207-216.Full text not available from this repository.
The aim of this study was to develop mucoadhesive microspheres that can be utilised for the controlled release of triclosan in oral-care formulations, specifically dental pastes. Using a double-emulsion solvent evaporation technique, triclosan was incorporated into microspheres that were prepared from Gantrez™ MS-955, Carbopol™ 974P, polycarbophil or chitosan and the profiles for its release were established under simulated ‘in use’ conditions. Triclosan was rapidly released into a sodium lauryl sulphate containing buffer from all but the chitosan microspheres. The release of triclosan from microspheres suspended in a non-aqueous paste, was found to be sustained over considerable time-periods, which were influenced strongly by the nature of the polymeric carrier. For microspheres that were fabricated from Gantrez, Carbopol or polycarbophil, the release appeared to obey zero-order kinetics whereas in the case of chitosan-derived vehicles, the release profile fitted the Baker and Lonsdale model. The work has demonstrated that these polymeric microspheres, particularly those of chitosan, are promising candidates for the sustained release of triclosan in the oral cavity.
|Item Type:||Journal article|
|Uncontrolled Keywords:||Polymer microspheres; Triclosan; Double emulsion; Bioadhesion; Oral cavity; Release kinetics|
|Subjects:||B000 Health Professions > B200 Pharmacology Toxicology and Pharmacy > B240 Pharmaceutics|
|DOI (a stable link to the resource):||10.1016/j.ejpb.2004.07.007|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences|
|Depositing User:||editor spbs|
|Date Deposited:||07 Nov 2007|
|Last Modified:||11 Jun 2013 13:10|
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