Mucoadhesive, triclosan-loaded polymer microspheres for application to the oral cavity: preparation and controlled release characteristics

Kockisch, S., Rees, G.D., Tsibouklis, J. and Smart, J.D. (2005) Mucoadhesive, triclosan-loaded polymer microspheres for application to the oral cavity: preparation and controlled release characteristics European Journal of Pharmaceutics and Biopharmaceutics, 59 (1). pp. 207-216.

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Abstract

The aim of this study was to develop mucoadhesive microspheres that can be utilised for the controlled release of triclosan in oral-care formulations, specifically dental pastes. Using a double-emulsion solvent evaporation technique, triclosan was incorporated into microspheres that were prepared from Gantrez™ MS-955, Carbopol™ 974P, polycarbophil or chitosan and the profiles for its release were established under simulated ‘in use’ conditions. Triclosan was rapidly released into a sodium lauryl sulphate containing buffer from all but the chitosan microspheres. The release of triclosan from microspheres suspended in a non-aqueous paste, was found to be sustained over considerable time-periods, which were influenced strongly by the nature of the polymeric carrier. For microspheres that were fabricated from Gantrez, Carbopol or polycarbophil, the release appeared to obey zero-order kinetics whereas in the case of chitosan-derived vehicles, the release profile fitted the Baker and Lonsdale model. The work has demonstrated that these polymeric microspheres, particularly those of chitosan, are promising candidates for the sustained release of triclosan in the oral cavity.

Item Type:Journal article
Uncontrolled Keywords:Polymer microspheres; Triclosan; Double emulsion; Bioadhesion; Oral cavity; Release kinetics
Subjects:B000 Health Professions > B200 Pharmacology Toxicology and Pharmacy > B240 Pharmaceutics
DOI (a stable link to the resource):10.1016/j.ejpb.2004.07.007
Faculties:Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
ID Code:970
Deposited By:editor spbs
Deposited On:07 Nov 2007
Last Modified:11 Jun 2013 14:10

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