Kockisch, S., Rees, G.D., Young, S.A., Tsibouklis, J. and Smart, J.D. (2004) In situ evaluation of drug-loaded microspheres on a mucosal surface under dynamic test conditions International Journal of Pharmaceutics, 276 (1-2). pp. 51-58.Full text not available from this repository.
The ability of polymeric microspheres fabricated from Carbopol, polycarbophil, chitosan or Gantrez to retain a model hydrophilic drug (sodium fluorescein) was evaluated in situ, using a dynamic test system and image analysis. This technique used oesophageal tissues and simulated the physiological conditions within the oral cavity in terms of temperature, humidity and saliva flow. The point of sample application was observed over a 2 h period by means of a digital camera. No significant differences in fluorescein colour intensity was obtained for the Gantrez and chitosan particles over 100 min, indicate that these two polymers provide the possibility of prolonged action. Carbopol and polycarbophil particles became rapidly swollen and released the sodium fluorescein completely within 20 min. It was concluded that the test system allowed the evaluation of the in situ behaviour of test particles, in terms of their ability to retain a water-soluble, coloured marker in ‘dynamic’ test conditions, and that chitosan and Gantrez were promising candidates for the production of mucoadhesive, sustained-release microspheres for water-soluble materials.
|Item Type:||Journal article|
|Uncontrolled Keywords:||Bioadhesion; Mucoadhesion; Oral cavity; Chitosan; Poly(acrylic acid); Maleic anhydride copolymers|
|Subjects:||B000 Health Professions > B200 Pharmacology Toxicology and Pharmacy > B240 Pharmaceutics|
|DOI (a stable link to the resource):||10.1016/j.ijpharm.2004.02.020|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences|
|Depositing User:||editor spbs|
|Date Deposited:||07 Nov 2007|
|Last Modified:||11 Jun 2013 12:28|
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