The effect of reproductive compensation on recessive disorders within consanguineous human populations

Overall, A.D.J., Ahmad, M. and Nichols, R.A. (2002) The effect of reproductive compensation on recessive disorders within consanguineous human populations Heredity, 88 (6). pp. 474-479. ISSN 0018-067X

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Official URL: http://dx.doi.org/10.1038/sj/hdy/6800090

Abstract

We investigate the effects of consanguinity and population substructure on genetic health using the UK Asian population as an example. We review and expand upon previous treatments dealing with the deleterious effects of consanguinity on recessive disorders and consider how other factors, such as population substructure, may be of equal importance. For illustration, we quantify the relative risks of recessive lethal disorders by presenting some simple calculations that demonstrate the effect 'reproductive compensation' has on the maintenance of recessive alleles. The results show how reproductive compensation can effectively counteract the purging of deleterious alleles within consanguineous populations. Whereas inbreeding does not elevate the equilibrium frequency of affected individuals, reproductive compensation does. We suggest this effect must be built into interpretations of the incidence of genetic disease within populations such as the UK Asians. Information of this nature will benefit health care workers who inform such communities.

Item Type:Journal article
Uncontrolled Keywords:marriage; inbreeding; mortality; morbidity; genetic counselling
Subjects:C000 Biological and Biomedical Sciences > C400 Genetics
B000 Health Professions
DOI (a stable link to the resource):doi: 10.1038/sj/hdy/6800090
Faculties:Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
ID Code:944
Deposited By:editor spbs
Deposited On:01 Dec 2006
Last Modified:18 Jun 2010 12:29

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