Nanoparticle-mediated gene delivery to tumour neovasculature
Reynolds, A.R., Moghimi, S.M. and Hodivala-Dilke, K. (2003) Nanoparticle-mediated gene delivery to tumour neovasculature Trends in molecular medicine, 9 (1). pp. 2-4. ISSN 1471-4914Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/S1471-4914(02)00004-7
The αvβ3 integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of αvβ3-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.
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