Nanoparticle-mediated gene delivery to tumour neovasculature
Reynolds, A.R., Moghimi, S.M. and Hodivala-Dilke, K. (2003) Nanoparticle-mediated gene delivery to tumour neovasculature Trends in molecular medicine, 9 (1). pp. 2-4. ISSN 1471-4914
Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/S1471-4914(02)00004-7
The αvβ3 integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of αvβ3-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.
Repository Staff Only: item control page