Reynolds, A.R., Moghimi, S.M. and Hodivala-Dilke, K. (2003) Nanoparticle-mediated gene delivery to tumour neovasculature Trends in molecular medicine, 9 (1). pp. 2-4. ISSN 1471-4914Full text not available from this repository.
The αvβ3 integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of αvβ3-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.
|Item Type:||Journal article|
|Subjects:||C000 Biological and Biomedical Sciences|
|DOI (a stable link to the resource):||10.1016/S1471-4914(02)00004-7|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences|
|Depositing User:||editor spbs|
|Date Deposited:||08 Nov 2007|
|Last Modified:||18 Jun 2010 11:29|
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