Nanoparticle-mediated gene delivery to tumour neovasculature

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Reynolds, A.R., Moghimi, S.M. and Hodivala-Dilke, K. (2003) Nanoparticle-mediated gene delivery to tumour neovasculature Trends in molecular medicine, 9 (1). pp. 2-4. ISSN 1471-4914

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Official URL: http://dx.doi.org/10.1016/S1471-4914(02)00004-7

Abstract

The αvβ3 integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of αvβ3-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.

Item Type:	Journal article
Subjects:	C000 Biological and Biomedical Sciences
DOI (a stable link to the resource):	10.1016/S1471-4914(02)00004-7
Faculties:	Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
ID Code:	934
Deposited By:	editor spbs
Deposited On:	08 Nov 2007
Last Modified:	18 Jun 2010 12:29

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