Chemical analysis of aging: testing predictions from green theory
Ostler, E.L., Iqbal, A., Faragher, R.G.A., Naughton, D., Piper, M. and Partridge, L. (2011) Chemical analysis of aging: testing predictions from green theory In: 40th American Aging Association Annual Meeting 2011, 2011, Raleigh, North Carolina, 3-6 June, 2011.
Official URL: http://posters.f1000.com/P1743
Methods: Environmental and genetic interventions were applied to examine their effects on age-related changes in the chemical composition of Drosophila melanogaster. Novel analytical methods were developed and validated to investigate the accumulation, with age, of stable molecular damage in flies. Results: Cohorts of Drosophila with extended lifespans showed a reduced rate of accumulation of signals consistent with damage during ageing compared to wild-type cohorts cultured under normal conditions. Spectrometric analysis also revealed distinct age-associated qualitative changes. Main conclusion: This work represents the first use of a range of analytical techniques to characterise and quantify compounds associated with, and possibly causing, different rates of ageing in Drosophila melanogaster.
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