Microelectrode investigation of neuroneal ageing from a single identified neurone

Patel, B.A., Arundell, M., Parker, K.H., Yeoman, M.S. and O'Hare, D. (2010) Microelectrode investigation of neuroneal ageing from a single identified neurone Physical Chemistry Chemical Physics, 12 (34). pp. 10065-10072. ISSN 1463-9076

[img] Text
Patel_-_Microelectrode_investigation.pdf - Published Version
Restricted to Registered users only

Download (883kB)

Abstract

Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamineneurotransmitterserotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.

Item Type: Journal article
Additional Information: © Royal Society of Chemistry
Subjects: C000 Biological and Biomedical Sciences
DOI (a stable link to the resource): 10.1039/C0CP00310G
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
Depositing User: editor spbs
Date Deposited: 14 Sep 2011 16:15
Last Modified: 21 May 2014 11:01
URI: http://eprints.brighton.ac.uk/id/eprint/9167

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year