Microelectrode investigation of neuroneal ageing from a single identified neurone

Patel, B.A., Arundell, M., Parker, K.H., Yeoman, M.S. and O'Hare, D. (2010) Microelectrode investigation of neuroneal ageing from a single identified neurone Physical Chemistry Chemical Physics, 12 (34). pp. 10065-10072. ISSN 1463-9076

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Abstract

Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamineneurotransmitterserotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.

Item Type:Journal article
Additional Information:© Royal Society of Chemistry
Subjects:C000 Biological and Biomedical Sciences
DOI (a stable link to the resource):10.1039/C0CP00310G
Faculties:Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
ID Code:9167
Deposited By:editor spbs
Deposited On:14 Sep 2011 17:15
Last Modified:09 Oct 2013 14:50

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