Pacher, P., Mabley, J.G., Soriano, F.G., Liaudet, L., Komjati, K. and Szabo, C. (2002) Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation British Journal of Pharmacology, 135 (6). pp. 1347-1350. ISSN 0007-1188Full text not available from this repository.
Recent work has demonstrated the production of reactive oxygen and nitrogen species in the vasculature of aging animals. Oxidant induced cell injury triggers the activation of nuclear enzyme poly(ADP ribose) polymerase (PARP) leading to endothelial dysfunction in various pathophysiological conditions (reperfusion, shock, diabetes). Here we studied whether the loss of endothelial function in aging rats is dependent upon the PARP pathway within the vasculature. Young (3 months-old) and aging (22 months-old) Wistar rats were treated for 2 months with vehicle or the PARP inhibitor PJ34. In the vehicle-treated aging animals there was a significant loss of endothelial function, as measured by the relaxant responsiveness of vascular rings to acetylcholine. Treatment with PJ34, a potent PARP inhibitor, restored normal endothelial function. There was no impairment of the contractile function and endothelium-independent vasodilatation in aging rats. Furthermore, we found no deterioration in the myocardial contractile function in aging animals. Thus, intraendothelial PARP activation may contribute to endothelial dysfunction associated with aging.
|Item Type:||Journal article|
|Uncontrolled Keywords:||Aging; cardiac function; endothelial dysfunction; poly(ADP ribose) polymerase|
|Subjects:||A000 Medicine > A300 Clinical Medicine|
|DOI (a stable link to the resource):||10.1038/sj.bjp.0704627|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences|
|Depositing User:||editor spbs|
|Date Deposited:||01 Dec 2006|
|Last Modified:||25 Apr 2014 14:56|
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