Development of inlaid electrodes for whole column electrochemical detection

Seo, J., Cho, S., Lim, H., Park, J., Leow, P.L., Patel, B.A. and O'Hare, D. (2009) Development of inlaid electrodes for whole column electrochemical detection Lab on a Chip, 9 (15). pp. 2238-2244. ISSN 1473-0197

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Abstract

An electrochemical microfluidic device has been fabricated on PET (polyethylene terephthalate) substrate using an imprinting method. The imprinting transfers patterns from a stamp into a substrate mechanically. However, a blanket mould imprinting process has been introduced to embed the photolithographically produced gold metal electrode lines into the PET substrate resulting in an individually addressable array flush to better than 100 nm. The device formed one wall of a packed chromatography column. The array was electrochemically characterised using standard redox probes in both stagnant conditions and under flow. Both numerical modelling and experimental data show improved sensitivity under flow and a limiting current which scaled linearly with the cube root of the volume flow rate. A chromatographic separation of the bioanalytical significant neurotransmitter dopamine (DA) and its metabolite DOPAC was achieved and electrochemically detected at multiple locations within the column. The PET device was stable and robust to leaks to pressures well in excess of those required for chromatographic separations.

Item Type: Journal article
Subjects: C000 Biological and Biomedical Sciences
DOI (a stable link to the resource): 10.1039/B822045J
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
Depositing User: editor spbs
Date Deposited: 17 Sep 2010 13:58
Last Modified: 01 May 2012 15:26
URI: http://eprints.brighton.ac.uk/id/eprint/7686

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