Stent material surface and glucose activate mononuclear cells of contril, type 1 and type 2 diabetes subjects

Harrison, M., Siddiq, A., Guildford, A., Bone, A. and Santin, M. (2007) Stent material surface and glucose activate mononuclear cells of contril, type 1 and type 2 diabetes subjects Journal of Biomedical Materials Research Part A, 83A (1). pp. 52-57. ISSN 1549-3296

Full text not available from this repository.

Abstract

In stent restenosis (ISR) has been described as an unaccomplished tissue healing and its rate is particularly high in diabetic patients. Evidence has been collected which relates the formation of ISR proteoglycan-rich neointimal tissue to the accumulation and protracted activation of macrophages around the stent metal struts. Here, the in vitro activation of mononuclear cells adhering to stainless steel (a material of choice in stent manufacturing) from control and diabetic (types 1 and 2) subjects was assessed in the presence of different glucose levels. The results showed that cells from the control and type 1 diabetes groups produced significantly higher levels of TGF-beta1 when adhering on stainless steel (p = 0.04 and p = 0.01), but a significant PDGF-BB secretion was observed only in control subjects. When tested at physiological glucose concentration, the effect of the stainless steel on control cells was more pronounced. The present study shows that mononuclear cells adhering onto stainless steel secrete growth factors relevant to ISR. Cells from diabetic subjects seem to secrete relatively higher levels of PDGF under hyperglycaemic conditions regardless of the substrate exposed thus offering an explanation for the higher incidence of restenosis in these patients.

Item Type: Journal article
Subjects: C000 Biological and Biomedical Sciences
DOI (a stable link to the resource): 10.1002/jbm.a.31204
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
Depositing User: editor spbs
Date Deposited: 31 Aug 2010 14:02
Last Modified: 08 Jan 2014 16:59
URI: http://eprints.brighton.ac.uk/id/eprint/7625

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year