In vitro host response assessment of biomaterials for cardiovascular stent manufacture

Santin, M., Mikhalovska, L.I., Lloyd, A.W., Mikhalovsky, S.V., Sigfrid, L.A., Denyer, S.P., Field, S.N. and Teer, D. (2004) In vitro host response assessment of biomaterials for cardiovascular stent manufacture Journal of materials science: materials in medicine, 15 (4). pp. 473-477. ISSN 1573-4838

Full text not available from this repository.

Abstract

The deployment of a vascular stent during angioplasty has greatly reduced the risks of restenosis. However, the presence of the device still induces a host response as well as a mechanical action on the blood vessel wall and an alteration of the haemodynamics. Platelet and inflammatory cells can adhere on the stent surface and be activated to produce biochemical signals able to stimulate an excessive proliferation of the smooth muscle cells with the consequent obstruction of the vessel lumen. For these reasons, the host response to two of the materials used in stent manufacture, stainless steel and diamond-like carbon, was investigated in vitro. The data showed that stainless steel induced a higher level of host response both in terms of platelet aggregation and macrophage activation. However, the spreading of inflammatory cells was more accentuated on diamond-like carbon. The inflammatory cells produced levels of platelet-derived growth factor, a key signal in smooth muscle cell proliferation, similar to stainless steel thus suggesting that carbon coatings may not be able to prevent restenosis.

Item Type: Journal article
Subjects: F000 Physical Sciences > F200 Materials Science
DOI (a stable link to the resource): 10.1023/B:JMSM.0000021123.51752.11
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Biomedical Materials
Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
Depositing User: editor spbs
Date Deposited: 29 Nov 2006
Last Modified: 18 Jun 2010 11:29
URI: http://eprints.brighton.ac.uk/id/eprint/747

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year