Campbell, S.C., Aldibbiat, A., Marriott, Claire, Landy, C., Ali, T., Ferris, W.F., Butler, C.S., Shaw, J.A. and Macfarlane, Wendy (2008) Selenium stimulates pancreatic beta cell gene expression and enhances islet function FEBS Letters, 582 (15). pp. 2333-2337. ISSN 0014-5793Full text not available from this repository.
The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, activating the −2715 to −1960 section of the Ipf1 gene promoter. Selenium increased both Ipf1 and insulin mRNA levels in Min6 cells and stimulated increases in insulin content and insulin secretion in isolated primary rat islets of Langerhans. These data are the first to implicate selenium in the regulation of specific beta-cell target genes and suggest that selenium potentially promotes an overall improvement in islet function.
|Item Type:||Journal article|
|Uncontrolled Keywords:||Beta-cell; Islets of Langerhans ; Transcription; Selenium; IPF1|
|Subjects:||C000 Biological and Biomedical Sciences|
|DOI (a stable link to the resource):||10.1016/j.febslet.2008.05.038|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences|
|Depositing User:||Sarah Flux|
|Date Deposited:||24 Aug 2010 12:36|
|Last Modified:||26 Mar 2015 12:33|
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