Selenium stimulates pancreatic beta cell gene expression and enhances islet function

Campbell, S.C., Aldibbiat, A., Marriott, C., Landy, C., Ali, T., Ferris, W.F., Butler, C.S., Shaw, J.A. and Macfarlane, W.M. (2008) Selenium stimulates pancreatic beta cell gene expression and enhances islet function FEBS Letters, 582 (15). pp. 2333-2337. ISSN 0014-5793

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Official URL: http://www.febsletters.org/article/S0014-5793(08)0...

Abstract

The present study investigated the role of selenium in the regulation of pancreatic beta-cell function. Utilising the mouse beta-cell line Min6, we have shown that selenium specifically upregulates Ipf1 (insulin promoter factor 1) gene expression, activating the −2715 to −1960 section of the Ipf1 gene promoter. Selenium increased both Ipf1 and insulin mRNA levels in Min6 cells and stimulated increases in insulin content and insulin secretion in isolated primary rat islets of Langerhans. These data are the first to implicate selenium in the regulation of specific beta-cell target genes and suggest that selenium potentially promotes an overall improvement in islet function.

Item Type:Journal article
Uncontrolled Keywords:Beta-cell; Islets of Langerhans ; Transcription; Selenium; IPF1
Subjects:C000 Biological and Biomedical Sciences
DOI (a stable link to the resource):10.1016/j.febslet.2008.05.038
Faculties:Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
ID Code:7466
Deposited By:Sarah Flux
Deposited On:24 Aug 2010 13:36
Last Modified:31 Mar 2014 15:48

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