The interactions of bisphosphonates in solution and as coatings on hydroxyapatite with osteoblasts

Ganguli, A., Henderson, C., Grant, M.H., Meikle, S.T., Lloyd, A.W. and Goldie, I. (2002) The interactions of bisphosphonates in solution and as coatings on hydroxyapatite with osteoblasts Journal of Materials Science: Materials in Medicine, 13 (10). pp. 923-931. ISSN 1573-4838

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Abstract

Aseptic loosening is one of the major causes of failure of artificial hip joints, and it can occur for several reasons, including osteolysis of the bone tissue in response to stress shielding or cellular reactions to wear debris. Any treatment of the prosthesis which could minimize the osteolytic response of bone tissue may be able to extend the life-time of the implant. Bisphosphonates are potent inhibitors of osteoclastic bone resorption, and they bind avidly to hydroxyapatite (HA). Coating the prostheses with bisphosphonates may therefore inhibit osteolysis. We have investigated the potential for this approach by determining whether bisphosphonates interact with osteoblasts in vitro. The effects of pamidronate (P), clodronate (C), and etidronate (E) in solution and when coated onto HA were investigated. P inhibited protein and collagen syntheses potently when in solution, but not after being bound to HA. When bound to HA, both P and C increased DNA, protein and collagen syntheses of osteoblasts and may encourage the osseointegration of implants. The pharmacological effects of the bisphosphonates studied altered dramatically after binding to HA. This must be fully investigated before this approach to prolonging prostheses stability can be evaluated.

Item Type: Journal article
Subjects: F000 Physical Sciences > F200 Materials Science
DOI (a stable link to the resource): 10.1023/A:1019892109411
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Biomedical Materials
Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
Depositing User: editor spbs
Date Deposited: 29 Nov 2006
Last Modified: 11 Nov 2013 15:34
URI: http://eprints.brighton.ac.uk/id/eprint/743

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