Biological evaluation and drug delivery application of cationically modified phospholipid polymers

Palmer, R.R., Lewis, A.L., Kirkwood, L.C., Rose, S.F., LLOYD, ANDREW, Vick, T.A. and Stratford, P.W. (2004) Biological evaluation and drug delivery application of cationically modified phospholipid polymers Biomaterials, 25 (19). pp. 4785-4796. ISSN 0142-9612

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Abstract

Phospholipid-like polymers based on 2-methacryloyloxyethyl phosphorylcholine containing varying amounts of the cationically charged monomer choline methacrylate (CMA) from 0 to 30 wt% have been prepared. Substrates coated with these materials were shown to bind significantly lower amounts of specific proteins compared to the uncoated control. ELISA assays demonstrated that fibrinogen did not bind appreciably to coatings containing 0–30% CMA, whereas albumin binding was seen to increase significantly as the CMA content of the coating increased. Platelet activation assays, measurement of plasma coagulation time and whole blood contact scanning electron micrography demonstrated that the haemocompatibility of the coatings was shown to be unaffected by the CMA component. The CMA polymer coatings have been shown to absorb/adsorb many different drug compounds covering a wide range of molecular weights and release these in a controlled fashion. The range of cationic polymers assessed can interact with the net negative charge found in many large therapeutic biomolecules, such as DNA fragments used in gene therapy, that may be of interest in the preventative treatment of conditions such as restenosis. Coronary stents coated with 6% or 20% CMA-containing polymers have been shown to load and release this type of genetic material irrespective of molecular weight of the biomolecule. Ex vivo and in vivo studies have shown that these compounds can be delivered to the stented section of the vessel with very low quantities delivered outside the vessel target area.

Item Type: Journal article
Uncontrolled Keywords: Phosphorylcholine coatings; Cationic charge; Protein adsorption; Haemocompatibility; Coronary stent; Drug delivery
Subjects: C000 Biological and Biomedical Sciences
C000 Biological and Biomedical Sciences > C700 Molecular Biology, Biophysics and Biochemistry
DOI (a stable link to the resource): 10.1016/j.biomaterials.2003.12.034
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Biomedical Materials
Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
Depositing User: Converis
Date Deposited: 29 Nov 2006
Last Modified: 07 Nov 2014 15:58
URI: http://eprints.brighton.ac.uk/id/eprint/737

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