Effects of phosphatidylserine coatings on titanium on inflammatory cells and cell-induced mineralisation in vitro

Bosetti, M., Lloyd, A.W., Santin, M., Denyer, S.P. and Cannas, M. (2005) Effects of phosphatidylserine coatings on titanium on inflammatory cells and cell-induced mineralisation in vitro Biomaterials, 26 (36). pp. 7572-7578. ISSN 0142-9612

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Abstract

Ideally an active bone biomaterial should increase the mineralisation rate at the bone healing sites, keeping at the same time the inflammation process to levels required for tissue regeneration. Our studies suggest that in addition to improving the nucleation process for new bone formation, coating titanium with phospholipids may reduce the inflammatory response, which was shown to vary depending on the formulation employed. As phosphatidylserine reduced the inflammatory response to the greatest extent, in the second part of this study we examined its effect on osteoblast mineralisation. These studies demonstrated that phosphatidylserine improves the nucleation process for bone formation, by promoting the formation of bone-like tissue, so the high mineralisation potential of phosphatidylserine-coated titanium, together with the lower level of inflammatory response, supports the further development of this technology for coating osteointegrative devices.

Item Type: Journal article
Uncontrolled Keywords: Mineralisation; Phosphatidylserine; Titanium; Inflammation
Subjects: C000 Biological and Biomedical Sciences
C000 Biological and Biomedical Sciences > C700 Molecular Biology, Biophysics and Biochemistry
DOI (a stable link to the resource): 10.1016/j.biomaterials.2005.05.033
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Biomedical Materials
Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
Depositing User: editor spbs
Date Deposited: 29 Nov 2006
Last Modified: 06 Nov 2013 16:00
URI: http://eprints.brighton.ac.uk/id/eprint/735

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