Occupational risks for uveal melanoma results from a case-control study in nine European countries

Lutz, J. M., Cree, I., Sabroe, S., Kvist, T., Clausen, L., Alfonso, N., Ahrens, W., Ballard, T., Bell, J., Cyr, D., Eriksson, M., Fevotte, J., Guenel, P., Hardell, L., Jokel, K.H., Miranda, A., Merletti, F., Morales-Suarez-Varela, M.M., Stengrevics, A. and Lynge, E (2005) Occupational risks for uveal melanoma results from a case-control study in nine European countries Cancer Causes and Control, 16 (4). pp. 437-447. ISSN 0957-5243

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Official URL: http://link.springer.com/article/10.1007%2Fs10552-...

Abstract

Objective Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors. Methods A population based case-control study was undertaken during 1995–1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job exposure matrix. In total, 320 uveal melanoma cases were eligible at pathology review, and 292 cases were interviewed, participation 91%. Out of 3357 population controls, 2062 were interviewed, 61%, and out of 1272 cancer controls 1094 were interviewed, 86%. Results Using population controls, occupational exposure to sunlight was not associated with an increased risk (RR=1.24, 95% CI=0.88-1.74), while an excess risk found with use of colon cancer controls was attributed to confounding factors. An excess risk in welders was restricted to the French part of the data. Cooks, RR=2.40; cleaners, RR 2.15; and laundry workers, RR=3.14, were at increased risk of uveal melanoma. Conclusion Our study does overall not support an association between occupational sunlight exposure and risk of uveal melanoma. The finding of an excess risk of eye melanoma in cooks in several European countries is intriguing.

Item Type:Journal article
Subjects:B000 Health Professions > B500 Public Health
DOI (a stable link to the resource):10.1007/s10552-004-5029-6
Faculties:Faculty of Health and Social Sciences > School of Health Professions
ID Code:605
Deposited By:editor health
Deposited On:01 Dec 2006
Last Modified:16 May 2013 12:54

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