Walsh, J.C., Horne, R., Dalton, M., Burgess, A.P. and Gazzard, B.G. (2001) Reasons for non-adherence to antiretroviral therapy: patients' perspectives provide evidence of multiple causes Aids Care, 13 (6). pp. 709-720. ISSN 0954-0121Full text not available from this repository.
The objective of the study was to define common reasons for non-adherence (NA) to highly active antiretroviral therapy (HAART) and the number of reasons reported by non-adherent individuals. A confidential questionnaire was administered to HIV-seropositive patients taking proteinase inhibitor based HAART. Median self-reported adherence was 95% (n = 178, range = 60-100%). The most frequent reasons for at least 'sometimes' missing a dose were eating a meal at the wrong time (38.2%), oversleeping (36.3%), forgetting (35.0%) and being in a social situation (30.5%). The mean number of reasons occurring at least 'sometimes' was 3.2; 20% of patients gave six or more reasons; those reporting the lowest adherence reported a significantly greater numbers of reasons („ = - 0.59; p < 0.001). Three factors were derived from the data by principal component analysis reflecting 'negative experiences of HAART', 'having a low priority for taking medication' and 'unintentionally missing doses', accounting for 53.8% of the variance. On multivariate analysis only the latter two factors were significantly related to NA (odds ratios 0.845 and 0.849, respectively). There was a wide spectrum of reasons for NA in our population. The number of reasons in an individual increased as adherence became less. A variety of modalities individualized for each patient are required to support patients with the lowest adherence.
|Item Type:||Journal article|
|Subjects:||A000 Medicine > A900 Medicine not elsewhere classified
B000 Health Professions
|DOI (a stable link to the resource):||10.1080/09540120120076878|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences|
|Depositing User:||editor spbs|
|Date Deposited:||29 Nov 2006|
|Last Modified:||06 Feb 2014 11:37|
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