West, S.L., Salvage, J.P., Lobb, E.J., Armes, S.P., Billingham, N.C., Lewis, A.L., Hanlon, G.W. and Lloyd, A.W. (2004) The biocompatibility of crosslinkable copolymer coatings containing sulfobetaines and phosphobetaines Biomaterials, 25 (7-8). pp. 1195-1204. ISSN 0142-9612Full text not available from this repository.
The comparison of copolymers containing sulfobetaine or phosphobetaine moieties for use as potential biocompatible coatings has been investigated. Two statistical copolymers were produced by a free radical polymerisation technique, one based on a sulfobetaine and the other on a phosphobetaine, both with a silyl group component to allow thermal crosslinking after coating. PMMA and glass discs were dip-coated with the polymers and their properties were compared to the uncoated controls. Bacterial adhesion to these coated materials was assessed using Staphylococcus epidermidis, Staphylococcus aureus and Pseudomonas aeruginosa. Human macrophages and granulocytes were used to assess the adhesion and activation of inflammatory cells whilst mouse 3T3 fibroblast cells were used to assess the propensity for the materials to support fibroblast cell adhesion. In all cases the polymer coatings reduced cell adhesion with respect to the base materials. The phosphobetaine-based copolymer coatings were shown to be markedly superior to the sulfobetaine-based copolymer coatings.
|Item Type:||Journal article|
|Uncontrolled Keywords:||Polysulfobetaine; Polyphosphobetaine; Bioinert coatings; Cell adhesion|
|Subjects:||C000 Biological and Biomedical Sciences
B000 Health Professions > B200 Pharmacology Toxicology and Pharmacy
|DOI (a stable link to the resource):||10.1016/j.biomaterials.2003.08.010|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Biomedical Materials|
|Depositing User:||editor spbs|
|Date Deposited:||29 Nov 2006|
|Last Modified:||07 Nov 2013 11:25|
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