Fraud, S., Maillard, J.Y., Kaminski, M.A. and Hanlon, G.W. (2005) Activity of amine oxide against biofilms of Streptococcus mutans: a potential biocide for oral care formulations Journal of Antimicrobial Chemotherapy, 56 (4). pp. 672-677. ISSN 1460-2091Full text not available from this repository.
Aims: To assess the potential bactericidal activity of amine oxide (C10-C16-alkyldimethyl N-oxides) against Streptococcus mutans grown as planktonic suspension and as biofilm on hydroxyapatite discs, and its ability to control acidification of the media. Methods: Amine oxide bacteriostasis was investigated using the Bioscreen C Microbiological Growth Analyser, while a standard suspension test was used to determine its bactericidal efficacy. In addition, the lethal activity of amine oxide was studied against sedimentation biofilms of S. mutans on hydroxyapatite (HA) discs and resuspended biofilms. Several parameters were considered such as the surfactant concentration, pH, the starting inoculum and the maturity of the biofilm. Results: Amine oxide was bacteriostatic against planktonic S. mutans at a low concentration (0.006% v/v) and highly bactericidal against S. mutans in suspension or in a mature biofilm on hydroxyapatite, although the concentration required to achieve the latter effect was four times higher. The activity of amine oxide against biofilms depended upon its concentration and the age of the biofilm. In addition, amine oxide pre-treatment of the HA discs did not affect the growth of the biofilm. Finally, amine oxide did not prevent the acidification of the medium, although lower pHs had a potentiating effect on amine oxide activity. Conclusion: Amine oxide showed high potential for controlling early biofilms caused by periodontal bacteria. Further investigations should be carried out, particularly on the potential toxicity of amine oxide and its efficacy in complex formulations for oral care products.
|Item Type:||Journal article|
|Uncontrolled Keywords:||biocides; dental plaque; killing kinetics; biofilms|
|Subjects:||B000 Health Professions > B900 Others in Health Professions
A000 Medicine > A400 Clinical Dentistry
|DOI (a stable link to the resource):||10.1093/jac/dki325|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences|
|Depositing User:||editor spbs|
|Date Deposited:||29 Nov 2006|
|Last Modified:||17 Apr 2014 12:50|
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