Oxidative DNA damage induced by high glucose and its suppression in human umbilical vein endothelial cells

Abstract

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or 5 days in high glucose (45 mM) compared with normal glucose (5 mM) medium (P<
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es increased in a time-dependent manner under high glucose treatment (3 days: P<
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a time-dependent manner under high glucose treatment (3 days: P<0.05, 5 days: P<
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aken up poorly into the cells, gave a slight increase in FPG-sensitive sites (P<
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ich are inhibitors of glycation, decreased the levels of FPG-sensitive sites (P<
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lyoxal and 3-DG at a concentration of 100 μg/ml induced FPG-sensitive sites (P<
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d 3-DG at a concentration of 100 μg/ml induced FPG-sensitive sites (P<0.001, P<
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	XML::LibXML::parse_string('XML::LibXML=HASH(0x2af1ffddd820)', '<fragment>In order to investigate the mechanism of the produc...') called at /home/eprints3/perl_lib/EPrints/XML/LibXML.pm line 106
	EPrints::XML::parse_xml_string('<fragment>In order to investigate the mechanism of the produc...') called at /home/eprints3/perl_lib/EPrints/Extras.pm line 85
	eval {...} called at /home/eprints3/perl_lib/EPrints/Extras.pm line 85
	EPrints::Extras::render_xhtml_field('EPrints::Session=HASH(0x2af1fd8ba370)', 'EPrints::MetaField::Longtext=HASH(0x2af1fe54ed30)', 'In order to investigate the mechanism of the production of ox...', 'undef', 'undef', 'EPrints::DataObj::EPrint=HASH(0x2af201c12d30)') called at /home/eprints3/perl_lib/EPrints/MetaField.pm line 960
	EPrints::MetaField::call_property('EPrints::MetaField::Longtext=HASH(0x2af1fe54ed30)', 'render_value', 'EPrints::Session=HASH(0x2af1fd8ba370)', 'EPrints::MetaField::Longtext=HASH(0x2af1fe54ed30)', 'In order to investigate the mechanism of the production of ox...', 'undef', 'undef', 'EPrints::DataObj::EPrint=HASH(0x2af201c12d30)') called at /home/eprints3/perl_lib/EPrints/MetaField.pm line 622
	EPrints::MetaField::render_value('EPrints::MetaField::Longtext=HASH(0x2af1fe54ed30)', 'EPrints::Session=HASH(0x2af1fd8ba370)', 'In order to investigate the mechanism of the production of ox...', 'undef', 'undef', 'EPrints::DataObj::EPrint=HASH(0x2af201c12d30)') called at /home/eprints3/perl_lib/EPrints/DataObj.pm line 759
	EPrints::DataObj::render_value('EPrints::DataObj::EPrint=HASH(0x2af201c12d30)', 'abstract') called at /home/eprints3/archives/brighton/cfg/cfg.d/eprint_render.pl line 182
	EPrints::Config::brighton::__ANON__('EPrints::DataObj::EPrint=HASH(0x2af201c12d30)', 'EPrints::Session=HASH(0x2af1fd8ba370)', 'undef') called at /home/eprints3/perl_lib/EPrints/Repository.pm line 1170
	eval {...} called at /home/eprints3/perl_lib/EPrints/Repository.pm line 1170
	EPrints::Repository::call('EPrints::Repository=HASH(0x2af1ffd3e330)', 'eprint_render', 'EPrints::DataObj::EPrint=HASH(0x2af201c12d30)', 'EPrints::Session=HASH(0x2af1fd8ba370)', 'undef') called at /home/eprints3/perl_lib/EPrints/DataObj/EPrint.pm line 1717
	EPrints::DataObj::EPrint::render('EPrints::DataObj::EPrint=HASH(0x2af201c12d30)') called at /home/eprints3/perl_lib/EPrints/DataObj/EPrint.pm line 1564
	EPrints::DataObj::EPrint::generate_static('EPrints::DataObj::EPrint=HASH(0x2af201c12d30)') called at /home/eprints3/perl_lib/EPrints/Update/Abstract.pm line 85
	EPrints::Update::Abstract::update('EPrints::Repository=HASH(0x2af1ffd3e330)', 'en', 580, '/archive/00/00/05/80/') called at /home/eprints3/perl_lib/EPrints/Apache/Rewrite.pm line 210
	EPrints::Apache::Rewrite::handler('Apache2::RequestRec=SCALAR(0x2af1fd8b5040)') called at -e line 0
	eval {...} called at -e line 0