The role of angiotensin II in cognition and behaviour

Gard, Paul (2002) The role of angiotensin II in cognition and behaviour European Journal of Pharmacology, 438 (1-2). pp. 1-14. ISSN 0014-2999

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Polymorphisms of the renin–angiotensin system are associated with cardiovascular disorders, possibly as a consequence of increased brain angiotensin II activity. Within the brain, angiotensin controls blood pressure, fluid balance and hormone secretion; it also influences behaviour: reduction of central angiotensin function has both antidepressant-like and axiolytic-like actions. Evidence concerning the role of the renin–angiotensin system in learning and memory is contradictory, although more studies support the proposal that angiotensin reduces cognitive function. Studies of renin–angiotensin system genotype and psychological status have suggested an association between the angiotensin-converting enzyme deletion allele and age related cognitive decline, but a greater prevalence of the insertion allele in Alzheimer's disease. The deletion allele has also been associated with depressive illness, as has the M allele of the angiotensinogen gene although other studies have failed to replicate these findings. The role of the brain renin–angiotensin system in human psychopathology remains to be fully explored.

Item Type: Journal article
Uncontrolled Keywords: Renin–angiotensin system; Affective disorder; Cognition; Memory
Subjects: B000 Health Professions > B200 Pharmacology Toxicology and Pharmacy
DOI (a stable link to the resource): 10.1016/S0014-2999(02)01283-9
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
Depositing User: editor spbs
Date Deposited: 29 Nov 2006
Last Modified: 19 Mar 2015 10:13

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