Strain differences in the anxiolytic effects of losartan in the mouse

Gard, P.R., Haigh, S.J., Cambursano, P.T. and Warrington, C.A. (2001) Strain differences in the anxiolytic effects of losartan in the mouse Pharmacology biochemistry and behavior, 69 (1-2). pp. 35-40. ISSN 0091-3057

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Official URL: http://dx.doi.org/10.1016/S0091-3057(01)00491-9

Abstract

Anxiolytic effects of the angiotensin AT1 receptor antagonist losartan were studied in the elevated plus maze (EPM) and the light/dark test (LDT) in different mouse strains as were responses to angiotensin II and acetylcholine in isolated ascending colon. There were no significant strain differences in behaviour on the EPM, and diazepam was anxiolytic in C57BL/6, DBA/2 and BKW mice. Losartan was anxiolytic in BKW only. In the LDT, there were significant strain differences, with BKW mice exhibiting greatest anxiety-like behaviour; losartan was ineffective in this test. In vitro responses to angiotensin II and acetylcholine were significantly smaller in BKW than in C57BL/6 and DBA/2. These results indicate that the mouse strain exhibiting least angiotensin receptor function is the most responsive to the anxiolytic effects, suggesting a possible relationship between angiotensin receptor function and anxiolytic response to losartan.

Item Type:Journal article
Uncontrolled Keywords:Losartan; Strain; Anxiolytic; Elevated plus maze; Light/dark test
Subjects:B000 Health Professions > B200 Pharmacology Toxicology and Pharmacy
DOI (a stable link to the resource):10.1016/S0091-3057(01)00491-9
Faculties:Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
ID Code:561
Deposited By:editor spbs
Deposited On:29 Nov 2006
Last Modified:18 Jun 2010 12:28

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