Yeoman, M.S. and Faragher, R.G.A. (2001) Ageing and the nervous system: insights from studies on invertebrates Biogerontology, 2 (2). pp. 85-97. ISSN 1573-6768Full text not available from this repository.
Abstract Ageing can have profound effects on the post-mitotic organ ofbehaviour, the brain. As yet the precise causes of thesedeleterious effects are unknown. However, clear insights intothe putative mechanisms and consequences of ageing in the CNShave been achieved through the use of invertebrate models. It isnow clear that ageing alters the endogenous properties ofneurones, their morphology, the efficacy of the connections thatthe neurones make with their targets and may even lead to neuroneloss. While the precise mechanisms underlying these changes arepresently unclear clues from post-mitotic organisms such as C.elegans have provided putative targets which are currently beinginvestigated. It is clear to date that the age-induced changesin CNS function observed in invertebrates are conserved inmammalian species and that further work on invertebrates mayprovide informative insights in to the mechanisms of neuronalageing.
|Item Type:||Journal article|
|Uncontrolled Keywords:||ageing - central nervous system - growth factors - invertebrate - neurone loss - synaptic efficacy|
|Subjects:||B000 Health Professions > B100 Anatomy Physiology and Pathology
A000 Medicine > A300 Clinical Medicine
|DOI (a stable link to the resource):||doi.10.1023/A:1011597420036|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Disease Process > Ageing
Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
|Depositing User:||editor spbs|
|Date Deposited:||29 Nov 2006|
|Last Modified:||18 Jun 2010 11:28|
Actions (login required)
Downloads per month over past year