Pyrrolidine dithiocarbamate reduces renal dysfunction and injury caused by ischemia/reperfusion of the rat kidney

Chatterjee, P.K., Bianca, R.D.D., Sivarajah, A., McDonald, M.C., Cuzzocrea, S. and Thiemermann, C. (2003) Pyrrolidine dithiocarbamate reduces renal dysfunction and injury caused by ischemia/reperfusion of the rat kidney European Journal of Pharmacology, 482 (1-3). pp. 271-280. ISSN 0014-2999

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Abstract

Dithiocarbamates can modulate the expression of genes associated with inflammation or development of ischemia/reperfusion injury. Here, we investigate the effects of pyrrolidine dithiocarbamate, an inhibitor of nuclear factor (NF)-κB activation, on the renal dysfunction and injury caused by ischemia/reperfusion of the rat kidney. Bilateral clamping of renal pedicles (45 min) followed by reperfusion (6 h) caused significant renal dysfunction and marked renal injury. Pyrrolidine dithiocarbamate (100 mg/kg, administered i.v.) significantly reduced biochemical and histological evidence of renal dysfunction and injury caused by ischemia/reperfusion of the rat kidney. Furthermore, pyrrolidine dithiocarbamate markedly reduced the expression of inducible nitric oxide synthase (iNOS) protein and significantly reduced serum levels of nitric oxide. Finally, pyrrolidine dithiocarbamate inhibited the activation of NF-κB by preventing its translocation from the cytoplasm into the nuclei of renal cells. These results demonstrate that pyrrolidine dithiocarbamate reduces renal ischemia/reperfusion injury and that dithiocarbamates may provide beneficial actions against ischemic acute renal failure.

Item Type: Journal article
Uncontrolled Keywords: Renal/kidney; reperfusion-injury; Dithiocarbamates; Pyrrolidine dithiocarbamate; Nuclear factor-κB; inducible nitric oxide synthase; Nitric oxide
Subjects: B000 Health Professions > B100 Anatomy Physiology and Pathology
DOI (a stable link to the resource): 10.1016/j.ejphar.2003.09.071
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
Depositing User: editor spbs
Date Deposited: 06 Nov 2007
Last Modified: 17 Apr 2014 09:50
URI: http://eprints.brighton.ac.uk/id/eprint/428

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