Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development

Adu, Jimi, Leong, F.T., Smith, N., Leek, J.P., Markham, A.F., Robinson, P.A. and Mighell, A.J. (2002) Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development Mechanisms of Development, 119 (S1). pp. 43-47. ISSN 0925-4773

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We report the initial characterization of mOb1 (Odd homeoBox 1), which encodes an atypical 73 amino acid K50-homeodomain protein localised in the cytoplasm and absent from nuclei during mouse development. Conserved orthologues were present in man, rat, cow, pig and chicken, but not in fish, amphibians or invertebrates. Temporo-spatial patterns of mOb1 transcript and mOb1 protein expression were coincident in developing mouse embryos. Cardiac expression was first observed at E8.25 in linear heart tube myocardium and briefly in both horns of the sinus venosus. Myocardial expression peaked at E13.5, where after it diminished and was not detectable above background by adulthood. At no stage was expression observed in endocardium, endocardial cushion tissue, the coronary arteries or great vessels. At E13.5 and E15.5, mOb1 expression broadened to include skeletal muscle, stratified epithelium (upper aerodigestive tract and skin), epithelium of developing airways, vibrissae, midbrain/hindbrain junction, meninges, mesenchymal cellular condensations that preceded cartilage formation and chondrocytes.

Item Type: Journal article
Uncontrolled Keywords: Homeodomain; odd homeobox 1; cytoplasm; myocardium; skeletal muscle; chondrocyte; meninges; squamous epithelium; respiratory epithelium; development
Subjects: B000 Health Professions > B200 Pharmacology Toxicology and Pharmacy
DOI (a stable link to the resource): 10.1016/S0925-4773(03)00090-X
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
Depositing User: editor spbs
Date Deposited: 08 Nov 2007
Last Modified: 05 Mar 2015 15:08

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