Azo compounds in colon-specific drug delivery
Roldo, M, Barbu, E, Brown, J.F, Laight, D.W, Smart, J.D and Tsibouklis, J (2007) Azo compounds in colon-specific drug delivery Expert Opinion on Drug Delivery, 4 (5). pp. 547-560. ISSN 1742-5247
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Official URL: http://dx.doi.org/10.1517/17425247.4.5.547
Azo compounds have the potential to act as drug carriers that facilitate the selective release of therapeutic agents to the colon, and also to effect the oral administration of those macromolecular drugs that require colon-specific drug delivery. With some further research-driven refinements, these materials may lead to more efficient treatments for local conditions, such as colonic cancer or inflammatory bowel disease. This article provides an overview of the azo-based systems developed to date, identifies the requirements for an ideal carrier, and highlights the directions for further developments in the field of azo group-facilitated colonic delivery.
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