Neurite outgrowths of neurons with neurotrophin-caoted carbon nanotubes
Matsumoto, K., Sato, C., Naka, Y., Kitazawa, A., Whitby, R.L.D. and Shimizu, N. (2007) Neurite outgrowths of neurons with neurotrophin-caoted carbon nanotubes Journal of Bioscience and Bioengineering, 103 . pp. 216-220. ISSN 1347-4421
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Multiwalled carbon nanotubes (CNTs) coated with neurotrophin were used to regulate the differentiation and survival of neurons. Neurotrophin (nerve growth factor [NGF] or brain-derived neurotrophic factor [BDNF]) was covalently bound to CNTs modified by amino groups using a 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) reagent. The CNTs coated with NGF or BDNF promoted the neurite outgrowths of neurons in the same manner as soluble NGF and soluble BDNF. By enzyme-linked immunosorbent assay (ELISA), we demonstrated that neurotrophin-coated CNTs carry neurotrophin. These results suggest that neurotrophin-coated CNTs have biological activity and stimulate the neurite outgrowths of neurons.
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