Orally administered, colon-specific mucoadhesive azopolymer particles for the treatment of inflammatory bowel disease: an in vivo study

Roldo, M., Barbu, E., Brown, J.F., Laight, D.W., Smart, J.D. and Tsibouklis, J. (2006) Orally administered, colon-specific mucoadhesive azopolymer particles for the treatment of inflammatory bowel disease: an in vivo study Journal of Biomedical Materials Research Part A, 79A (3). pp. 706-715. ISSN 1549-3296

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.3...

Abstract

Radiolabeled congeners of a series of azopolymers have been synthesized and characterized. The in vivo (rat) gastrointestinal transit profile of millimeter-sized particles of these azopolymers has been determined and used to facilitate the selection of a candidate material for therapeutic applications. The efficacy of the selected material as a protective coating for the colonic mucosa has been tested in a hapten-reactivated, in vivo model of inflammatory bowel disease: 7 days after reactivation of the condition, the myeloperoxidase activity of animals that had received doses of the selected azopolymer was determined to be at the same level as that of healthy animals or that of the negative control group, highlighting the therapeutic promise of this material. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006

Item Type:Journal article
Uncontrolled Keywords:mucoadhesion; azopolymers; colon specific drug delivery; inflammatory bowel disease (IBD); 4,4′divinylazobenzene
Subjects:C000 Biological and Biomedical Sciences
DOI (a stable link to the resource):10.1002/jbm.a.30810
Faculties:Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Biomedical Materials
Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Chemical Biology
ID Code:2977
Deposited By:editor spbs
Deposited On:07 Nov 2007
Last Modified:24 Oct 2013 12:25

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