Developments in microarray technologies

Howbrook, D.N., van der Valk, A.M., O'Shaughnessy, M.C., Sarker, Dipak, Baker, S.C. and Lloyd, Andrew (2003) Developments in microarray technologies Drug Disocvery Today, 8 (14). pp. 642-651. ISSN 1359-6446

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The focus of high-throughput drug discovery has progressed through the genome and the transcriptome and is now moving towards more difficult problems in assessing the proteome, glycome and metabolome. Microarrays are currently the major tool in the assessment of gene expression via cDNA or RNA analysis; however, they are also used to screen libraries of proteins and small molecules. Microarrays have helped to extract more information from smaller sample volumes and enabled the incorporation of low-cost high-throughput assays in the drug discovery process. The technology continues to develop and is being rapidly transferred into more challenging areas, with the potential to further aid and enhance the drug discovery process through the development of, for example, proteomic, glycomic and tissue arrays

Item Type: Journal article
Subjects: C000 Biological and Biomedical Sciences
DOI (a stable link to the resource): 10.1016/S1359-6446(03)02773-9
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Biomedical Materials
Depositing User: editor spbs
Date Deposited: 08 Nov 2007
Last Modified: 26 Mar 2015 11:15

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