Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D

Mabley, J.G, Wallace, R, Pacher, P, Murphy, K and Szabo, C (2007) Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D International Journal of Molecular Medicine, 19 (6). pp. 947-952. ISSN 1791-244X

Full text not available from this repository.

Abstract

Vitamin D is well characterized for its role in mineral homeostasis and maintenance of normal skeletal architecture. Vitamin D has been demonstrated to exert anti-inflammatory effects in a variety of disease states including diabetes, arthritis and inflammatory bowel disease. In these diseases poly[adenosine diphosphate (ADP)-ribose] polymerase (PARP) inhibitors have also proved effective as anti-inflammatory agents. Here we present data demonstrating that the active metabolite of vitamin D, 1α,25-dihydroxy-vitamin D3, is a PARP inhibitor. UV irradiation-mediated PARP activation in human keratinocytes can be inhibited by treatment with vitamin D, 7-dehydrocholesterol or 1α,25-dihydroxyvitamin D3. Inhibition of cytochrome P450 reversed the PARP inhibitory action of vitamin D and 7-dehydrocholesterol, indicating that conversion to 1α,25-dihydroxyvitamin D3 mediates their PARP inhibitory action. Vitamin D may protect keratinocytes against over-activation of PARP resulting from exposure to sunlight. PARP inhibition may contribute to the pharmacological and anti-inflammatory effects of vitamin D.

Item Type: Journal article
Subjects: C000 Biological and Biomedical Sciences > C700 Molecular Biology, Biophysics and Biochemistry
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Disease Process > Diabetes
Depositing User: editor spbs
Date Deposited: 08 Nov 2007
Last Modified: 18 Jun 2010 11:33
URI: http://eprints.brighton.ac.uk/id/eprint/2771

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year