Mabley, J.G., Wallace, R., Pacher, P., Murphy, K. and Szabo, C. (2007) Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D International Journal of Molecular Medicine, 19 (6). pp. 947-952. ISSN 1791-244XFull text not available from this repository.
Vitamin D is well characterized for its role in mineral homeostasis and maintenance of normal skeletal architecture. Vitamin D has been demonstrated to exert anti-inflammatory effects in a variety of disease states including diabetes, arthritis and inflammatory bowel disease. In these diseases poly[adenosine diphosphate (ADP)-ribose] polymerase (PARP) inhibitors have also proved effective as anti-inflammatory agents. Here we present data demonstrating that the active metabolite of vitamin D, 1α,25-dihydroxy-vitamin D3, is a PARP inhibitor. UV irradiation-mediated PARP activation in human keratinocytes can be inhibited by treatment with vitamin D, 7-dehydrocholesterol or 1α,25-dihydroxyvitamin D3. Inhibition of cytochrome P450 reversed the PARP inhibitory action of vitamin D and 7-dehydrocholesterol, indicating that conversion to 1α,25-dihydroxyvitamin D3 mediates their PARP inhibitory action. Vitamin D may protect keratinocytes against over-activation of PARP resulting from exposure to sunlight. PARP inhibition may contribute to the pharmacological and anti-inflammatory effects of vitamin D.
|Item Type:||Journal article|
|Subjects:||C000 Biological and Biomedical Sciences > C700 Molecular Biology, Biophysics and Biochemistry|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Disease Process > Diabetes|
|Depositing User:||editor spbs|
|Date Deposited:||08 Nov 2007|
|Last Modified:||07 Nov 2014 09:07|
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