The current chemical utility of marine and terrestrial filamentous fungi in side-chain chemistry

Hunter, A.C (2007) The current chemical utility of marine and terrestrial filamentous fungi in side-chain chemistry Current Organic Chemistry, 11 (8). pp. 665-677. ISSN 1385-2728

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Abstract

This review focuses on three aspects of the application of marine and terrestrial filamentous fungi to side-chain chemistry from 2000 to early 2006. The first section covers the generation of novel biologically active side-chain containing metabolites. This includes a range of antibiotic, cytotoxic and novel bioactive compounds. The second section discusses the use of these fungi both whole cell and lipases of fungal origin in the chemical modification of side-chains. Examples include reductive desymmetrization of pro-chiral ketones, dynamic kinetic resolution and unique reactions. The final section details the degradation of side-chains by fungi and includes lignin and steroid transformations for determination metabolism and the generation of new skeletal structure.

Item Type: Journal article
Subjects: F000 Physical Sciences > F100 Chemistry
DOI (a stable link to the resource): 10.2174/138527207780598756
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Chemical Biology
Depositing User: editor spbs
Date Deposited: 08 Nov 2007
Last Modified: 18 Jun 2010 11:33
URI: http://eprints.brighton.ac.uk/id/eprint/2757

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