Transmembrane ion transport by calixarenes and their derivatives

Iqbal, K.S.J and Cragg, P.J. (2007) Transmembrane ion transport by calixarenes and their derivatives Dalton Transactions, 1 . pp. 26-32. ISSN 1477-9226

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Official URL: http://pubs.rsc.org/en/Journals/JournalIssues/DT

Abstract

Regulation of transmembrane ion transport is a vital aspect of bioinorganic chemistry. To understand how this highly selective process occurs, how it can become impaired and how impairment may be treated, model compounds are useful tools. Several systems are presently being explored but one of the most widely applicable combines a rigid macrocycle, capable of size-based ion recognition, with membrane-spanning substituents that allow the target ions to traverse a phospholipid bilayer. The calixarene class of macrocycles is ideally suited to this task. This article sets out the biological background to transmembrane ion transport, the methods available to study the phenomenon, examples of model compounds, and proposes areas of further study.

Item Type:Journal article
Subjects:F000 Physical Sciences > F100 Chemistry
Faculties:Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Chemical Biology
ID Code:2745
Deposited By:editor spbs
Deposited On:08 Nov 2007
Last Modified:29 Jan 2014 13:55

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