A new class of bioactive and biodegradable soybean-based bone fillers

Santin, M, Morris, C, Standen, G, Nicolais, L and Ambrosio, L (2007) A new class of bioactive and biodegradable soybean-based bone fillers Biomacromolecules, 8 (9). pp. 2706-2711. ISSN 1526-4602

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Abstract

The reconstruction of large bone defects in periodontal, maxillofacial, and orthopedic surgery relies on the implantation of biomaterials able to support the growth of new tissue. None of the materials currently available is able to combine all the properties required, which are (i) easy handling, (ii) biodegradation, (iii) low immunogenicity, and more importantly, (iv) induction of tissue regeneration. A new class of biodegradable biomaterials has been obtained by simple thermosetting of defatted soybean curd. The final material can be processed into films, porous scaffolds, and granules for different surgical needs. When incubated in physiological solutions the material shows water uptake of 80%, elongation at break of 0.9 mm/mm, and 25% (w/w) degradation in 7 days. Soybean-based biomaterial granules are shown to reduce the activity of the monocytes/macrophages and of the osteoclasts and to induce osteoblast differentiation in vitro, thus demonstrating a bone regeneration potential suitable for many clinical applications.

Item Type: Journal article
Subjects: C000 Biological and Biomedical Sciences
C000 Biological and Biomedical Sciences > C700 Molecular Biology, Biophysics and Biochemistry
DOI (a stable link to the resource): 10.1021/bm0703362
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Biomedical Materials
Depositing User: editor spbs
Date Deposited: 08 Nov 2007
Last Modified: 21 Sep 2010 08:12
URI: http://eprints.brighton.ac.uk/id/eprint/2715

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