Regulation of the pdx1 gene promoter in pancreatic beta-cells

Campbell, S.C. and Macfarlane, Wendy (2002) Regulation of the pdx1 gene promoter in pancreatic beta-cells Biochemical and Biophysical Research Communications, 299 (2). pp. 277-284. ISSN 1090-2104

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In the adult pancreas the expression of the transcription factor PDX1 is mainly restricted to the-cells of the islets of Langerhans. In this study we have identified a region of the pdx1promoter between -2715 and -1960 which was essential to direct pancreatic islet-cell-specific expression of PDX1. We have also begun for the first time to understand the complex nutritional and hormonal regulation controlling PDX1 expression. The current study has established the fact that glucose, GLP-1, insulin,T3, HB-EGF, and TNF- all positively regulate the PDX1 gene promoter in pancreatic-cells. This study represents the first detailed exploration of the nutritional and hormonal regulation of this vital -cell gene.

Item Type: Journal article
Subjects: C000 Biological and Biomedical Sciences
DOI (a stable link to the resource): 10.1016/S0006-291X(02)02633-5
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Disease Process > Diabetes
Depositing User: editor spbs
Date Deposited: 08 Nov 2007
Last Modified: 26 Mar 2015 12:35

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