Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat

Nesic, Z., Todorovic, Z., Stojanovic, R., Basta-Jovanovic, G., Radojevic-Skodric, S., Velickovic, R., Chatterjee, P.K., Thiemermann, C. and Prostran, M. (2006) Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat Journal of Pharmacological Sciences, 102 (4). pp. 413-417. ISSN 1347-8613

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Abstract

The effect of acute pretreatment with a single dose of simvastatin (1 mg/kg, i.v.; 30 min before ischemia) on renal dysfunction caused by ischemia-reperfusion (I/R) injury in the rat was investigated. I/R injury was induced by clamping both renal vascular pedicles for 45 min, followed by 4 h of reperfusion with saline (2 ml/kg per hour). Simvastatin significantly improved both parameters of glomerular and tubular dysfunction (e.g., creatinine levels and fractional excretion of Na+, respectively) and especially improved the histological score, compared to control I/R-injured rats treated with saline or 10% DMSO only.

Item Type: Journal article
Subjects: F000 Physical Sciences > F100 Chemistry
C000 Biological and Biomedical Sciences > C700 Molecular Biology, Biophysics and Biochemistry
DOI (a stable link to the resource): 10.1024/jphs.SCE06002X
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Chemical Biology
Depositing User: editor spbs
Date Deposited: 07 Jan 2008
Last Modified: 22 Oct 2014 09:42
URI: http://eprints.brighton.ac.uk/id/eprint/2621

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