Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat
Nesic, Z, Todorovic, Z, Stojanovic, R, Basta-Jovanovic, G, Radojevic-Skodric, S, Velickovic, R, Chatterjee, P.K, Thiemermann, C and Prostran, M (2006) Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat Journal of Pharmacological Sciences, 102 (4). pp. 413-417. ISSN 1347-8613
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Official URL: http://dx.doi.org/10.1024/jphs.SCE06002X
The effect of acute pretreatment with a single dose of simvastatin (1 mg/kg, i.v.; 30 min before ischemia) on renal dysfunction caused by ischemia-reperfusion (I/R) injury in the rat was investigated. I/R injury was induced by clamping both renal vascular pedicles for 45 min, followed by 4 h of reperfusion with saline (2 ml/kg per hour). Simvastatin significantly improved both parameters of glomerular and tubular dysfunction (e.g., creatinine levels and fractional excretion of Na+, respectively) and especially improved the histological score, compared to control I/R-injured rats treated with saline or 10% DMSO only.
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