Physiological activities of carbon monoxide-releasing molecules: Ca ira

Chatterjee, P.K. (2007) Physiological activities of carbon monoxide-releasing molecules: Ca ira British Journal of Pharmacology, 150 (8). pp. 961-962. ISSN 0007-1188

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Abstract

In this issue of British Journal of Pharmacology, Megías and colleagues demonstrate how preincubation of human colonic Caco-2 cells with CORM-2, a carbon monoxide releasing molecule (CO-RM), reduces the expression of inducible nitric oxide synthase, interleukin (IL)-6 and IL-8 caused by proinflammatory cytokines. A role for IL-6 in the regulation of metalloproteinase (MMP)-7 expression by CORM-2 is described. However, it is the demonstration that CORM-2 inhibits MMP-7 or matrilysin expression, which is most intriguing as this small MMP has been implicated in carcinogenesis. Thus, CO-RMs appear to now possess chemoprotective properties and, in this particular case, may influence inflammation-induced colon carcinogenesis via modulation of nuclear factors participating in the transcription of genes implicated in the development of intestinal inflammation and cancer. This report opens yet another door for research involving these exciting molecules and it is now clear that further discoveries of the beneficial properties of CO-RMs will go on.

Item Type: Journal article
Subjects: F000 Physical Sciences > F100 Chemistry
C000 Biological and Biomedical Sciences > C700 Molecular Biology, Biophysics and Biochemistry
DOI (a stable link to the resource): 10.1038/sj.bjp.0707185
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Chemical Biology
Depositing User: editor spbs
Date Deposited: 08 Nov 2007
Last Modified: 22 Oct 2014 10:59
URI: http://eprints.brighton.ac.uk/id/eprint/2620

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