The in vitro adsorption of cytokines by polymer-pyrolysed carbon
HOWELL, CAROL, SANDEMAN, SUSAN, PHILLIPS, GARY, LLOYD, ANDREW, Davies, J.G, MIKHALOVSKY, SERGEY, Tennison, S.R., Rawlinson, A.P., Kozynchenko, O.P., Owen, H.L.H., Gaylor, J.D.S., Rouse, J.J. and Courtney, J.M. (2006) The in vitro adsorption of cytokines by polymer-pyrolysed carbon Biomaterials, 27 (30). pp. 5286-5291. ISSN 0142-9612
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Official URL: http://dx.doi.org/10.1016/j.biomaterials.2006.05.0...
This study investigated a range of phenol–formaldehyde–aniline-based pyrolysed carbon matrices and their component materials, for their ability to adsorb a range of inflammatory cytokines crucial to the progression of sepsis. The efficiency of adsorption of the target molecules from human plasma was assessed and compared to that of Adsorba® 300C, a commercially available cellulose-coated activated charcoal. Results indicate that a number of the primary carbon/resin materials demonstrate efficient adsorption of the cytokines studied here (TNF, IL-6 and IL-8), comparable to other adsorbents under clinical investigation. Our findings also illustrate that these adsorbent capabilities are retained when the primary particles are combined to form a pyrolysed carbon matrix. This capability will enable the engineering of the carbon matrix porosity allowing a blend of carbonised particle combinations to be tailored for maximum adsorption of inflammatory cytokines. The present findings support further investigation of this carbon material as a combined carbon-based filtration/adsorbent device for direct blood purification.
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