Howell, Carol, Sandeman, Susan, Phillips, Gary, Lloyd, Andrew, Davies, J.G., Mikhalovsky, Sergey, Tennison, S.R., Rawlinson, A.P., Kozynchenko, O.P., Owen, H.L.H., Gaylor, J.D.S., Rouse, J.J. and Courtney, J.M. (2006) The in vitro adsorption of cytokines by polymer-pyrolysed carbon Biomaterials, 27 (30). pp. 5286-5291. ISSN 0142-9612Full text not available from this repository.
This study investigated a range of phenol–formaldehyde–aniline-based pyrolysed carbon matrices and their component materials, for their ability to adsorb a range of inflammatory cytokines crucial to the progression of sepsis. The efficiency of adsorption of the target molecules from human plasma was assessed and compared to that of Adsorba® 300C, a commercially available cellulose-coated activated charcoal. Results indicate that a number of the primary carbon/resin materials demonstrate efficient adsorption of the cytokines studied here (TNF, IL-6 and IL-8), comparable to other adsorbents under clinical investigation. Our findings also illustrate that these adsorbent capabilities are retained when the primary particles are combined to form a pyrolysed carbon matrix. This capability will enable the engineering of the carbon matrix porosity allowing a blend of carbonised particle combinations to be tailored for maximum adsorption of inflammatory cytokines. The present findings support further investigation of this carbon material as a combined carbon-based filtration/adsorbent device for direct blood purification.
|Item Type:||Journal article|
|Subjects:||C000 Biological and Biomedical Sciences|
|DOI (a stable link to the resource):||10.1016/j.biomaterials.2006.05.041|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences|
|Date Deposited:||08 Nov 2007|
|Last Modified:||20 Apr 2015 15:08|
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