Hunter, A.C. and Priest, S.M. (2006) An efficient one-pot synthesis generating 4-ene-3,6-dione functionalised steroids from steroidal 5-en-3 beta-ols using a modified Jones oxidation methodology Steroids, 71 (1). pp. 30-33. ISSN 0039-128XFull text not available from this repository.
Steroids with 4-ene-3,6-dione functionality have application in natural product chemistry, as synthetic intermediates and as aromatase inhibitors. Here, we report a two-phase oxidation of a range of steroidal 5-en-3β-ols into corresponding 4-ene-3,6-diones using a modified Jones oxidation. The new reaction affords high yields (77–89%) of product in relatively short reaction times (1–2 h). The simplicity of this reaction gives significant advantages over previously reported methodologies.
|Item Type:||Journal article|
|Uncontrolled Keywords:||4-Ene-3,6-dione; Jones oxidation; One-pot synthesis; Aromatase inhibitor|
|Subjects:||C000 Biological and Biomedical Sciences|
|DOI (a stable link to the resource):||10.1016/j.steroids.2005.07.007|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences|
|Depositing User:||editor spbs|
|Date Deposited:||08 Nov 2007|
|Last Modified:||23 Apr 2014 12:12|
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