Modulation of the BK Channel by estrogens: examination at a single channel level

De Wet, H., Allen, Marcus, Holmes, C., Stobbart, M., Lippiat, J.D. and Callaghan, R. (2006) Modulation of the BK Channel by estrogens: examination at a single channel level Molecular Membrane Biology, 23 (5). pp. 420-429. ISSN 1464-5203

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BK channels regulate vascular tone by hyperpolarizing smooth muscle in response to fluctuating calcium concentrations. Oestrogen has been reported to lower blood pressure by increasing BK channel open probability through direct binding to the regulatory 1-subunit(s) associated with the channel. The present investigation demonstrates that 17-oestradiol activates the BK channel complex by increasing the burst duration of channel openings. A subconductance state was observed in 25% of recordings following the addition of 17-oestradiol and could reflect uncoupling between the pore forming 1-subunit and the regulatory 1-subunit. We also present evidence that more than one 1-subunit is required to facilitate binding of 17-oestradiol to the channel complex

Item Type: Journal article
Uncontrolled Keywords: Maxi-K channel; oestrogen; planar lipid bilayers; subconductance state
Subjects: C000 Biological and Biomedical Sciences > C700 Molecular Biology, Biophysics and Biochemistry
DOI (a stable link to the resource): 10.1080/09687860600802803
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences > Chemical Biology
Depositing User: editor spbs
Date Deposited: 08 Nov 2007
Last Modified: 05 Mar 2015 14:41

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