The future of genomic research in athletic performance and adaptation to training

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Wang, Guan, Tanaka, M., Eynon, Nir, North, Kathryn N., Williams, A.G., Collins, Malcolm, Moran, Colin N., Britton, Steven L., Fuku, Noriyuki, Ashley, Euan, Klissouras, Vassilis, Lucia, Alejandro, Ahmetov, Ildus I., Geus, Eco de, Alsayrafi, Mohammed and Pitsiladis, Yannis (2016) The future of genomic research in athletic performance and adaptation to training In: Posthumus, M. and Collins, M., eds. Genetics and sports. Karger, Basel, Switzerland, pp. 55-67. ISBN 9783318030112

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Abstract

Despite numerous attempts to discover genetic variants associated with elite athletic performance, an individual's trainability and injury predisposition, there has been limited progress to date. Past reliance on candidate gene studies focusing predominantly on genotyping a limited number of genetic variants in small, often heterogeneous cohorts has not generated results of practical significance. Hypothesis-free genome-wide approaches will in the future provide more comprehensive coverage and in-depth understanding of the biology underlying sports-related traits and related genetic mechanisms. Large, collaborative projects with sound experimental designs (e.g. clearly defined phenotypes, considerations and controls for sources of variability, and necessary replications) are required to produce meaningful results, especially when a hypothesis-free approach is used. It remains to be determined whether the novel approaches under current implementation will result in findings with real practical significance. This review will briefly summarize current and future directions in exercise genetics and genomics.

Item Type: Chapter in book
Subjects: C000 Biological and Biomedical Sciences > C600 Sport and Exercise Science
L000 Social Sciences > L300 Sociology > L311 Sport and Leisure
B000 Health Professions > B100 Anatomy Physiology and Pathology
B000 Health Professions > B100 Anatomy Physiology and Pathology > B120 Physiology
B000 Health Professions > B100 Anatomy Physiology and Pathology > B110 Anatomy
B000 Health Professions > B100 Anatomy Physiology and Pathology > B190 Anatomy, Physiology and Pathology not elsewhere classified
C000 Biological and Biomedical Sciences > C400 Genetics
C000 Biological and Biomedical Sciences > C400 Genetics > C410 Applied genetics
C000 Biological and Biomedical Sciences > C400 Genetics > C420 Human genetics
C000 Biological and Biomedical Sciences > C400 Genetics > C440 Molecular genetics
C000 Biological and Biomedical Sciences > C400 Genetics > C490 Genetics not elsewhere classified
DOI (a stable link to the resource): 10.1159/000445241
Depositing User: Converis
Date Deposited: 03 Aug 2016 03:02
Last Modified: 03 Aug 2016 08:23
URI: http://eprints.brighton.ac.uk/id/eprint/15861

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