Similar inflammatory responses following sprint interval training performed in hypoxia and normoxia

Warning

As of July 2018 University of Brighton Repository is no longer updated. Please see our new repository at http://research.brighton.ac.uk.

Richardson, Alan, Relf, Rebecca, Saunders, A. and Gibson, Oliver (2016) Similar inflammatory responses following sprint interval training performed in hypoxia and normoxia Frontiers in Physiology. ISSN 1664-042X

[img] Text
fphys-07-00332.pdf - Published Version
Available under License Creative Commons Attribution.

Download (1MB)

Abstract

Sprint interval training (SIT) is an efficient intervention capable of improving aerobic capacity and exercise performance. This experiment aimed to determine differences in training adaptations and the inflammatory responses following 2 weeks of SIT (30s maximal work, 4 min recovery; 4-7 repetitions) performed in normoxia or hypoxia. Forty-two untrained participants [(mean ± SD), age 21 ±1 yrs, body mass 72.1 ±11.4 kg and height 173 ±10 cm] were equally and randomly assigned to one of three groups; control (CONT; no training, n = 14), normoxic (NORM; SIT in FiO2: 0.21, n = 14) and normobaric hypoxic (HYP; SIT in FiO2: 0.15, n = 14). Participants completed a V̇O 2peak test, a time to exhaustion (TTE) trial (power = 80% V̇O2peak) and had haematological [haemoglobin (Hb), haematocrit (Hct)] and inflammatory markers [interleukin-6 (IL-6), tumor necrosis factor-α (TNFα)] measured in a resting state, pre and post SIT. V̇O2peak (mL.kg-1.min-1) improved in HYP (+11.9%) and NORM (+9.8%), but not CON (+0.9%). Similarly TTE improved in HYP (+32.2%) and NORM (+33.0%), but not CON (+3.4%) whilst the power at the anaerobic threshold (AT; W.kg-1) also improved in HYP (+13.3%) and NORM (+8.0%), but not CON (-0.3%). AT (mL.kg-1.min-1) improved in HYP (+9.5%), but not NORM (+5%) or CON (-0.3%). No between group change occurred in 30 s sprint performance or Hb and Hct. IL-6 increased in HYP (+17.4%) and NORM (+20.1%), but not CON (+1.2%) respectively. TNF-α increased in HYP (+10.8%) NORM (+12.9%) and CON (+3.4%). SIT in HYP and NORM increased VO2peak, power at AT and TTE performance in untrained individuals, improvements in AT occurred only when SIT was performed in HYP. Increases in IL-6 and TNFα reflect a training induced inflammatory response to SIT; hypoxic conditions do not exacerbate this.

Item Type: Journal article
Additional Information: © 2016 Richardson, Relf, Saunders and Gibson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission
Uncontrolled Keywords: High Intensity Training; Altitude; Endurance; Inflammation; Cytokine
Subjects: C000 Biological and Biomedical Sciences > C600 Sport and Exercise Science
L000 Social Sciences > L300 Sociology > L311 Sport and Leisure
B000 Health Professions > B100 Anatomy Physiology and Pathology > B120 Physiology
B000 Health Professions > B100 Anatomy Physiology and Pathology
B000 Health Professions > B100 Anatomy Physiology and Pathology > B190 Anatomy, Physiology and Pathology not elsewhere classified
DOI (a stable link to the resource): 10.3389/fphys.2016.00332
Depositing User: Converis
Date Deposited: 28 Jul 2016 03:01
Last Modified: 26 Sep 2016 11:01
URI: http://eprints.brighton.ac.uk/id/eprint/15823

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year