An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis


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Sandeman, Susan, Howell, Carol, Phillips, Gary, Zheng, Yishan, Standen, Guy, Pletzenauer, Robert, Pletzenauer, Andrew, Basnayake, Kolitha, Owen, Boyd, Holt, Stephen and Mikhalovsky, Sergey (2014) An adsorbent monolith device to augment the removal of uraemic toxins during haemodialysis Journal of Materials Science: Materials in Medicine, 25 (6). pp. 1589-1597. ISSN 0957-4530

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Adsorbents designed with porosity which allows the removal of protein bound and high molecular weight uraemic toxins may improve the effectiveness of haemodialysis treatment of chronic kidney disease (CKD). A nanoporous activated carbon monolith prototype designed for direct blood contact was first assessed for its capacity to remove albumin bound marker toxins indoxyl sulphate (IS), p-cresyl sulphate (p-CS) and high molecular weight cytokine interleukin-6 in spiked healthy donor studies. Haemodialysis patient blood samples were then used to measure the presence of these markers in pre- and post-dialysis blood and their removal by adsorbent recirculation of post-dialysis blood samples. Nanopores (20-100 nm) were necessary for marker uraemic toxin removal during in vitro studies. Limited removal of IS and p-CS occurred during haemodialysis, whereas almost complete removal occurred following perfusion through the carbon monoliths suggesting a key role for such adsorbent therapies in CKD patient care.

Item Type: Journal article
Additional Information: © The Author(s) 2014. This article is published with open access at
DOI (a stable link to the resource): 10.1007/s10856-014-5173-9
Depositing User: Converis
Date Deposited: 19 Dec 2014 15:53
Last Modified: 19 Dec 2014 15:57

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