Recognition by macrophages and liver cells of opsonized phospholipid vesicles and phospholipid headgroups

Moghimi, S.M. and Hunter, A.C. (2001) Recognition by macrophages and liver cells of opsonized phospholipid vesicles and phospholipid headgroups Pharmaceutical research, 18 (1). pp. 1-8. ISSN 0724-8741

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Abstract

The interaction of liposomes with blood proteins is believed to play a critical role in the clearance pharmacokinetics and tissue distribution of intravenously injected liposomes. In this article we have focused our discussion on the interaction of liposomes with key blood proteins, which include immunoglobulins, complement proteins, apolipoproteins, fetuin, von Willebrand factor, and thrombospondin, and their role in liposome recognition by professional phagocytes and nonmacrophage hepatic cells. Alternatively, macrophages as well as hepatocytes and liver endothelial cells may phagocytose/endocytose liposomes via direct recognition of phospholipid headgroups. A number of plasma membrane receptors such as lectin receptors, CD14, various classes of scavenger receptors (e.g., classes A, B, and D), Fc?RI and Fc?RII-B2 may participate in phospholipid recognition. These concepts are also discussed.

Item Type: Journal article
Additional Information: The original publication is available at www.springerlink.com
Subjects: B000 Health Professions > B200 Pharmacology Toxicology and Pharmacy > B240 Pharmaceutics
Faculties: Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences
Depositing User: editor spbs
Date Deposited: 08 Nov 2007
Last Modified: 18 Jun 2010 11:29
URI: http://eprints.brighton.ac.uk/id/eprint/1085

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