Moghimi, S.M. and Hunter, A.C. (2001) Recognition by macrophages and liver cells of opsonized phospholipid vesicles and phospholipid headgroups Pharmaceutical research, 18 (1). pp. 1-8. ISSN 0724-8741Full text not available from this repository.
The interaction of liposomes with blood proteins is believed to play a critical role in the clearance pharmacokinetics and tissue distribution of intravenously injected liposomes. In this article we have focused our discussion on the interaction of liposomes with key blood proteins, which include immunoglobulins, complement proteins, apolipoproteins, fetuin, von Willebrand factor, and thrombospondin, and their role in liposome recognition by professional phagocytes and nonmacrophage hepatic cells. Alternatively, macrophages as well as hepatocytes and liver endothelial cells may phagocytose/endocytose liposomes via direct recognition of phospholipid headgroups. A number of plasma membrane receptors such as lectin receptors, CD14, various classes of scavenger receptors (e.g., classes A, B, and D), Fc?RI and Fc?RII-B2 may participate in phospholipid recognition. These concepts are also discussed.
|Item Type:||Journal article|
|Additional Information:||The original publication is available at www.springerlink.com|
|Subjects:||B000 Health Professions > B200 Pharmacology Toxicology and Pharmacy > B240 Pharmaceutics|
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences|
|Depositing User:||editor spbs|
|Date Deposited:||08 Nov 2007|
|Last Modified:||18 Jun 2010 11:29|
Actions (login required)
Downloads per month over past year