GARD, PAUL (2010) Implications of the angiotensin converting enzyme gene insertion/deletion polymorphism in health and disease: a snapshot review International Journal of Molecular Epidemiology and Genetics, IJMEG, 1 (2). pp. 145-147. ISSN 1948-1756
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This review considers the 250+ papers concerning the association of the angiotensin converting enzyme (ACE) gene insertion/deletion polymorphism (rs1799752) and various disease conditions published in 2009. The deletion allele occurs in approximately 55% of the population and is associated with increased activity of the ACE enzyme. It might be predicted that the D allele, therefore, might be associated with pathologies involving increased activity of the renin-angiotensin system. The D allele was seen to be associated with an increased risk of hypertension, pre-eclampsia, heart failure, cerebral infarct, diabetic nephropathy, encephalopathy, asthma, severe hypoglycaemia in diabetes, gastric cancer (in Caucasians) and poor prognosis following kidney transplant. On the positive side, the D allele appears to offer protection against schizophrenia and chronic periodontitis and confers greater upper-body strength in old age. The I allele, meanwhile, offers improved endurance/athletic performance and aerobic capacity as determined by lung function tests, although it does increase the risk of oral squamous cell carcinoma and obstructive sleep apnoea in hypertensives.
|Item Type:||Journal article|
|Uncontrolled Keywords:||Angiotensin converting enzyme; ACE polymorphism; renin-angiotensin system; hypertension; heart failure; dementia; depression|
|Subjects:||B000 Health Professions > B200 Pharmacology Toxicology and Pharmacy
C000 Biological and Biomedical Sciences
|Faculties:||Faculty of Science and Engineering > School of Pharmacy and Biomolecular Sciences|
|Date Deposited:||12 Mar 2012 16:18|
|Last Modified:||21 May 2014 11:02|
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